This study aims to determine and examine empirical data related to the effect of online learning and students' mental health on high school students' learning requests. This study uses a survey method with a correlational and regression approach to quantitative data. The research population is high school students in South Tangerang City. The sample of this research is 80 respondents. Data was collected using a questionnaire technique. The type of analysis used is correlation and regression analysis which is described descriptively by using statistical data processing software SPSS version 26. The results of the study are: First, there is a significant effect of the influence of online learning on students' interest in learning with a correlation coefficient (r) of 0.466 and R2 by 21.8%. Second, there is a significant effect of mental health on students' interest in learning with a correlation coefficient (r) of 0.435 and R2 of 18.9%. Third, there is a significant effect of online learning and students' mental health together on interest in learning with r of 0.604 and R2 of 36.5%. = 17.200 + 0.455 X1 + 0.426 X2 Each increase in the score of the effect of online learning (X1) and mental health (X2) simultaneously, gives an effect on increasing student interest in learning (Y) of 0.881.