This research studies the sociological approach through a holistic pattern in solving the problem of homosexuality from the Qur’an perspective. This research is qualitative research that focuses on religious understanding as well as religious research. The conclusion of this research: First, the sociological approach through a holistic pattern in solving the problem of homosexuality from the Qur’an perspective is on attention, focus, objectives, and purposes in placing every individual. Second, according to the Qur’an perspective, the problem of homosexuality is an abomination (fâhisyah) because it deviates from the grand design of the creation of creatures in pairs between one gender and another. Thus, this problem must be handled based on a holistic pattern. Third, there are several factors that cause homosexuality. The experts are also not of the same opinion. Those several factors, among others: are biological, genetic and hormonal, psychodynamic, sociocultural, lack of religious understanding, education, family, and social life. Fourth, homosexuality gives negative impacts on health, education, faith, and social life such as venereal diseases, HIV/AIDS, and drug abuse. Fifth, the sociological approach through the holistic pattern from the Qur’an perspective applied in solving the problem of homosexuality covers the whole system: action, social, cultural, and personality.